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Brevinin1 HYba2
General Information
DCTPep ID DCTPep00662
Peptide Name Brevinin1 HYba2
Sequence FFPGIIKVAGAILPTAICAITKRC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Hep 3B | Childhood hepatocellular carcinoma | 85% Cytotoxicity=100µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 60% Hemolysis=50µM; 85% Hemolysis=100µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00662
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C117H195N29O27S2
Absent amino acids DEHMNQSWY
Theoretical pI 9.50
Acidic residues 0
Basic residues 3
Polar residues 6
Molecular weight (Average) 2504.13
Molecular weight (Monoisotopic) 2502.42
Common amino acids I
Net charge 3
Instability index (II) 33.09
Aliphatic index 126.25
Grand average of hydropathicity (GRAVY) 1.275
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.050, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28072492
Title Identification and characterization of novel host defense peptides from the skin secretion of the fungoid frog, Hydrophylax bahuvistara (Anura: Ranidae)
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.