AM-CATH21

General Information


DCTPep ID  DCTPep00666

Peptide Name   AM-CATH21

Sequence  GLFKKLRRKIKKGFKKIFKRL

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Not active up to 100 µg/ml MTT assay 24h 1

Hemolytic Activity  Sheep erythrocytes(Not active up to 300 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00666

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C127H222N38O22

Absent amino acids  ACDEHMNPQSTVWY

Theoretical pI  12.33

Acidic residues  0

Basic residues  11

Polar residues  2

Molecular weight (Average)  2633.4

Molecular weight (Monoisotopic)  2631.74

Common amino acids  K

Net charge  11

Instability index (II)  19.81

Aliphatic index  92.86

Grand average of hydropathicity (GRAVY)  -0.795

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28089718

Title  Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae

Doi 10.1016/j.dci.2017.01.011

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.