Peptide Libraray

AM-CATH36

General Information

DCTPep ID DCTPep00667

Peptide Name AM-CATH36

Sequence GLFKKLRRKIKKGFKKIFKRLPPIGVGVSIPLAGKR

Sequence Length 36

UniProt ID Not available

PubChem CID Not available

Origin Alligator mississippiensis

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Not active up to 100 µg/ml	MTT assay	24h	1

Hemolytic Activity Sheep erythrocytes(Not active up to 300 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00667

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C194H337N57O38

Absent amino acids CDEHMNQTWY

Theoretical pI 12.49

Acidic residues 0

Basic residues 13

Polar residues 6

Molecular weight (Average) 4076.17

Molecular weight (Monoisotopic) 4073.62

Common amino acids K

Net charge 13

Instability index (II) 29.96

Aliphatic index 105.56

Grand average of hydropathicity (GRAVY) -0.247

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28089718

Title Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae

Doi 10.1016/j.dci.2017.01.011

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available