Peptide Libraray

Bacteriocin TP

General Information

DCTPep ID DCTPep00670

Peptide Name Bacteriocin TP

Sequence ASVVNKLTGGVAGLLK

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Bacillus subtilis

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
NB4	Acute promyelocytic leukemia with PML-RARA ; Acute promyelocytic leukemia	IC50=11.479µM	MTT assay	48h	1
MKN 45	Gastric adenocarcinoma	IC50=4.686µM	MTT assay	48h	1

Hemolytic Activity Mouse erythrocytes: <10% Hemolysis=160µM; 10% Hemolysis=320µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00670

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C68H123N19O20

Absent amino acids CDEFHIMPQRWY

Theoretical pI 10.00

Acidic residues 0

Basic residues 2

Polar residues 6

Molecular weight (Average) 1526.84

Molecular weight (Monoisotopic) 1525.92

Common amino acids GLV

Net charge 2

Instability index (II) 15.97

Aliphatic index 140.00

Grand average of hydropathicity (GRAVY) 0.850

Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28254375

Title Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium

Doi 10.1016/j.ijantimicag.2016.12.012

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available