Peptide Libraray

Temporin-1Tb [L1F,N7L,L9del]-K

General Information

DCTPep ID DCTPep00694

Peptide Name Temporin-1Tb [L1F,N7L,L9del]-K

Sequence FLPIVGLLKSLLK

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=59µM	PI flow cytometric assay	24h	1

Hemolytic Activity Horse erythrocytes: <10% Hemolysis=48µM

Normal (non-cancerous) Cytotoxicity PBMC: IC50=52µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00694

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C72H125N15O15

Absent amino acids ACDEHMNQRTWY

Theoretical pI 10.00

Acidic residues 0

Basic residues 2

Polar residues 2

Molecular weight (Average) 1440.88

Molecular weight (Monoisotopic) 1439.95

Common amino acids L

Net charge 2

Instability index (II) -2.08

Aliphatic index 202.31

Grand average of hydropathicity (GRAVY) 1.531

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28443279

Title Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide

Doi 10.3389/fchem.2017.00024

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available