BP100 [Y10D]

General Information


DCTPep ID  DCTPep00697

Peptide Name   BP100 [Y10D]

Sequence  KKLFKKILKDL

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7/ADM Invasive breast carcinoma of no special type IC50=70.7±6.3µM MTT assay 48h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL24 positive; Chronic myeloid leukemia IC50=76.3±5.4µM MTT assay 48h 1
MCF-7 Invasive breast carcinoma of no special type IC50=77.9±6.7µM MTT assay 48h 1
K562/ADM Blast phase chronic myelogenous leukemia, BCR-ABL25 positive; Chronic myeloid leukemia IC50=82.5±6.8µM MTT assay 48h 1

Hemolytic Activity  Rabbit erythrocytes: 11% Hemolysis=160µM

Normal (non-cancerous) Cytotoxicity  GES-1: IC50>100µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C67H120N16O14

Absent amino acids  ACEGHMNPQRSTVWY

Theoretical pI  10.18

Acidic residues  1

Basic residues  5

Polar residues  0

Molecular weight (Average)  1373.79

Molecular weight (Monoisotopic)  1372.92

Common amino acids  K

Net charge  4

Instability index (II)  -10.22

Aliphatic index  141.82

Grand average of hydropathicity (GRAVY)  -0.391

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28474125

Title  Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities

Doi 10.1007/s00726-017-2434-1

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.