This work is licensed under a Creative Commons Attribution 4.0 International License.
BP100 [Y10R]
General Information
DCTPep ID DCTPep00704
Peptide Name BP100 [Y10R]
Sequence KKLFKKILKRL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7/ADM | Invasive breast carcinoma of no special type | IC50=57.3±4.5µM | MTT assay | 48h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=59.4±2.9µM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL25 positive; Chronic myeloid leukemia | IC50=60.8±5.3µM | MTT assay | 48h | 1 |
| K562/ADM | Blast phase chronic myelogenous leukemia, BCR-ABL26 positive; Chronic myeloid leukemia | IC50=71.2±4.7µM | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit erythrocytes: 5% Hemolysis=160µM
Normal (non-cancerous) Cytotoxicity GES-1: IC50>100µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H127N19O12
Absent amino acids ACDEGHMNPQSTVWY
Theoretical pI 11.39
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1414.89
Molecular weight (Monoisotopic) 1413.99
Common amino acids K
Net charge 6
Instability index (II) 19.42
Aliphatic index 141.82
Grand average of hydropathicity (GRAVY) -0.482
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28474125
Title Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.