Peptide Libraray

Sphistin (12-38)

General Information

DCTPep ID DCTPep00722

Peptide Name Sphistin (12-38)

Sequence KAKAKAVSRSARAGLQFPVGRIHRHLK

Sequence Length 27

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Not active up to 100 µg/ml	MTS assay	24h	1

Hemolytic Activity Crab haemocytes: Not active up to 100 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00722

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C132H228N48O31

Absent amino acids CDEMNTWY

Theoretical pI 12.48

Acidic residues 0

Basic residues 10

Polar residues 4

Molecular weight (Average) 2983.57

Molecular weight (Monoisotopic) 2981.77

Common amino acids A

Net charge 10

Instability index (II) 62

Aliphatic index 83.33

Grand average of hydropathicity (GRAVY) -0.563

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28600196

Title A truncated Sph12-38 with potent antimicrobial activity showing resistance against bacterial challenge in Oryzias melastigma

Doi 10.1016/j.fsi.2017.06.013

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available