Peptide Libraray

Reverse Tachyplesin [C3,7,12,16Del]

General Information

DCTPep ID DCTPep00728

Peptide Name Reverse Tachyplesin [C3,7,12,16Del]

Sequence RRRYIGRYVRFWK

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=12100µM	MTT assay	Not available	1

Hemolytic Activity Sheep erythrocytes: <1% Hemolysis=540µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00728

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C87H134N30O16

Absent amino acids ACDEHLMNPQST

Theoretical pI 11.84

Acidic residues 0

Basic residues 6

Polar residues 3

Molecular weight (Average) 1856.21

Molecular weight (Monoisotopic) 1855.06

Common amino acids R

Net charge 6

Instability index (II) 85.75

Aliphatic index 52.31

Grand average of hydropathicity (GRAVY) -1.446

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 4.568

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28641565

Title D-Amino Acid Analogues of the Antimicrobial Peptide CDT Exhibit Anti- Cancer Properties in A549, a Human Lung Adenocarcinoma Cell Line

Doi 10.2174/0929866524666170621093647

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available