This work is licensed under a Creative Commons Attribution 4.0 International License.
temporin-ITa
General Information
DCTPep ID DCTPep00752
Peptide Name temporin-ITa
Sequence FLGAIAQALTSLLGKL
Sequence Length 16
UniProt ID C0HL49
PubChem CID Not available
Origin skin secretions of the Italian stream frog Rana italica (Ranidae)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | LC50=100 μM | CellTiter-Glo Lumines- cent Cell Viability assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | LC50=40 μM | CellTiter-Glo Lumines- cent Cell Viability assay | 24h | 1 |
| A549 | Lung adenocarcinoma | LC50=45 μM | CellTiter-Glo Lumines- cent Cell Viability assay | 24h | 1 |
Hemolytic Activity mouse erythrocytes: LC50=22 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00752
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification α-amidated residue at the C-terminus
Other Modification α-amidated residue at the C-terminus
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) 1615.98
Molecular weight (Monoisotopic) 1614.97
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28699258
Title Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae)
Doi 10.1002/psc.3025
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.