This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclic Gomesin [PYA1G, C2,6,11,15SeCys]
General Information
DCTPep ID DCTPep00763
Peptide Name Cyclic Gomesin [PYA1G, C2,6,11,15SeCys]
Sequence GXRRLXYKQRXVTYXRGR
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL27 positive; Chronic myeloid leukemia | CC50=1.4±0.2µM | Resazurin assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | CC50=37.5±3.3µM | Resazurin assay | 24h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | CC50=38.5±4.8µM | Resazurin assay | 24h | 1 |
| MM96L | Melanoma | CC50=4.6±0.2µM | Resazurin assay | 24h | 1 |
| CRL-1739 | Human gastric adenocarcinoma cells | CC50=51.0±4.6µM | Resazurin assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | CC50>64µM | Resazurin assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 32.8±0.5% Hemolysis=64µM
Normal (non-cancerous) Cytotoxicity HFF-1: CC50=15.6±3.6µM; PBMC: CC50=15.5±0.8µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys15; Cys6<--->Cys11; NCB: Gly1<--->Arg18
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Se-Cys
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28741926
Title Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
Doi 10.1021/acschembio.7b00459
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.