Cyclic Gomesin [PYA1K;C2,6,11,15SeCys;L5Y;K8R]

General Information


DCTPep ID  DCTPep00767

Peptide Name   Cyclic Gomesin [PYA1K;C2,6,11,15SeCys;L5Y;K8R]

Sequence  KXRRYXYRQRXVTYXRGR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MM96L Melanoma CC50=2.3±0.2µM Resazurin assay 24h 1
MCF-7 Invasive breast carcinoma of no special type CC50=29.0±3.7µM Resazurin assay 24h 1
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia CC50=33.3±7.4µM Resazurin assay 24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma CC50=36.2±2.8µM Resazurin assay 24h 1
CRL-1739 Human gastric adenocarcinoma cells CC50=46.2±7.6µM Resazurin assay 24h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL28 positive; Chronic myeloid leukemia CC50=6.4±0.6µM Resazurin assay 24h 1

Hemolytic Activity  Human erythrocytes: 20.9±3.1% Hemolysis=64µM

Normal (non-cancerous) Cytotoxicity  HFF-1: CC50=30.8±2.0µM; PBMC: CC50=9.5±0.5µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys15; Cys6<--->Cys11; NCB: Gly1<--->Arg18

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Se-Cys

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28741926

Title  Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties

Doi 10.1021/acschembio.7b00459

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.