Gm

General Information


DCTPep ID  DCTPep00768

Peptide Name   Gm

Sequence  XCRRLCYKQRCVTYCRGR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Redesigned Spider Peptide

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MM96L Melanoma CC50=3.7 ± 0.2 µM Resazurin assay 18-24h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia CC50=3.8 ± 0.3 µM Resazurin assay 18-24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma CC50=54.1 ± 5.0 µM Resazurin assay 18-24h 1
CRL-1739 Gastric adenocarcinoma CC50=67.0 ± 5.0 µM Resazurin assay 18-24h 1

Hemolytic Activity  Human red blood cells (hRBCs): hemolysis(%)=30.7±8.1 with 64 μM of peptide

Normal (non-cancerous) Cytotoxicity  PBMCs: CC50=13.4±1.8 µM, testing time is 18-24h; HFF-1: CC50=49.9 ± 16.6 µM, testing time is 18-24h

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys15; Cys6<--->Cys11

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=N-terminal pyroglutamic acid

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28741926

Title  Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties

Doi 10.1021/acschembio.7b00459

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_814

DCTPep is developed by Dr.Zheng's team.