This work is licensed under a Creative Commons Attribution 4.0 International License.
As-CATH4
General Information
DCTPep ID DCTPep00770
Peptide Name As-CATH4
Sequence RRGLFKKLRRKIKKGFKKIFKRLPPVGVGVSIPLAGRR
Sequence Length 38
UniProt ID Not available
PubChem CID Not available
Origin Alligator sinensis
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | 26±0.9% Cell death=200µg/ml | MTT assay | 48h | 1 |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | 58±1.5% Cell death=200µg/ml | MTT assay | 48h | 1 |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | 58±1.5% Cell death=200µg/ml | MTT assay | 48h | 1 |
Hemolytic Activity Human erythrocytes: 4±0.5% Hemolysis=200µg/ml
Normal (non-cancerous) Cytotoxicity CHO: 55±2.5% Cell death=200µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00770
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C205H359N67O40
Absent amino acids CDEHMNQTWY
Theoretical pI 12.78
Acidic residues 0
Basic residues 15
Polar residues 6
Molecular weight (Average) 4402.53
Molecular weight (Monoisotopic) 4399.81
Common amino acids K
Net charge 15
Instability index (II) 53.31
Aliphatic index 97.37
Grand average of hydropathicity (GRAVY) -0.495
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28798159
Title As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.