Lavracin [D2G,P3K,Y4F]

General Information


DCTPep ID  DCTPep00772

Peptide Name   Lavracin [D2G,P3K,Y4F]

Sequence  WGKFFAGVKKLTKAILAVRA

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MEC-7 Invasive breast carcinoma of no special type EC50=25µM MTT assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HDME: Not active up to 100 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00772

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C107H174N28O22

Absent amino acids  CDEHMNPQSY

Theoretical pI  11.33

Acidic residues  0

Basic residues  5

Polar residues  3

Molecular weight (Average)  2204.73

Molecular weight (Monoisotopic)  2203.34

Common amino acids  AK

Net charge  5

Instability index (II)  4.02

Aliphatic index  107.50

Grand average of hydropathicity (GRAVY)  0.540

Half Life 
  2.8 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.495

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28799716

Title  Rational Design of Membrane-Pore-Forming Peptides.

Doi 10.1002/smll.201701316

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.