This work is licensed under a Creative Commons Attribution 4.0 International License.
Lavracin [A17G,V18E,R19I]
General Information
DCTPep ID DCTPep00773
Peptide Name Lavracin [A17G,V18E,R19I]
Sequence WDPYFAGVKKLTKAILGEIA
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MEC-7 | Invasive breast carcinoma of no special type | Not active up to 100 µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDME: Not active up to 100 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00773
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C107H166N24O27
Absent amino acids CHMNQRS
Theoretical pI 8.43
Acidic residues 2
Basic residues 3
Polar residues 4
Molecular weight (Average) 2220.64
Molecular weight (Monoisotopic) 2219.24
Common amino acids AK
Net charge 1
Instability index (II) 19.3
Aliphatic index 107.50
Grand average of hydropathicity (GRAVY) 0.250
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 3.148
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28799716
Title Rational Design of Membrane-Pore-Forming Peptides.
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.