This work is licensed under a Creative Commons Attribution 4.0 International License.
Lavracin [D2G,P3K,Y4F,A17G,V18E,R19I]
General Information
DCTPep ID DCTPep00774
Peptide Name Lavracin [D2G,P3K,Y4F,A17G,V18E,R19I]
Sequence WGKFFAGVKKLTKAILGEIA
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MEC-7 | Invasive breast carcinoma of no special type | EC50=25µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDME: Not active up to 100 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00774
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C106H169N25O24
Absent amino acids CDHMNPQRSY
Theoretical pI 10.00
Acidic residues 1
Basic residues 4
Polar residues 4
Molecular weight (Average) 2177.66
Molecular weight (Monoisotopic) 2176.28
Common amino acids K
Net charge 3
Instability index (II) 9.88
Aliphatic index 107.50
Grand average of hydropathicity (GRAVY) 0.495
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.526
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28799716
Title Rational Design of Membrane-Pore-Forming Peptides.
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.