This work is licensed under a Creative Commons Attribution 4.0 International License.
Ilamycin B1
General Information
DCTPep ID DCTPep00778
Peptide Name Ilamycin B1
Sequence XXLXAXX
Sequence Length 7
UniProt ID Not available
PubChem CID Not available
Origin Streptomyces atratus SCSIO ZH16
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50>50µM | MTT assay | Not available | 1 |
| CNE2 | unknow | IC50>50µM | MTT assay | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50>50µM | MTT assay | Not available | 1 |
| HepG2 | Hepatoblastoma | IC50>50µM | MTT assay | Not available | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50>50µM | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HL-7702 (L02): IC50>50µM; HUVEC: IC50>50µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: X1<--->X7
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28855504
Title Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents
Doi 10.1038/s41467-017-00419-5
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.