Ilamycin B2

General Information


DCTPep ID  DCTPep00779

Peptide Name   Ilamycin B2

Sequence  XXLXAXX

Sequence Length  7

UniProt ID  Not available

PubChem CID  Not available

Origin  Streptomyces atratus SCSIO ZH16

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma IC50=13.8 µM MTT assay Not available 1
MCF-7 Invasive breast carcinoma of no special type IC50=17.4 µM MTT assay Not available 1
CNE2 unknow IC50=24.5 µM MTT assay Not available 1
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=7.1 µM MTT assay Not available 1
HepG2 Hepatoblastoma IC50=8.9 µm MTT assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HL-7702 (L02): IC50=24.6 µM; HUVEC: IC50=18.6 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: X1<--->X7

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28855504

Title  Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Doi  10.1038/s41467-017-00419-5

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.