Peptide Libraray

LfcinB (17-31)

General Information

DCTPep ID DCTPep00792

Peptide Name LfcinB (17-31)

Sequence FKARRWQWRMKKLGA

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Bovine Lactoferricin

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-231	Breast adenocarcinoma	IC50>102 μM	MTT assay	2h	1
MDA-MB-468	Breast adenocarcinoma	IC50>102 μM	MTT assay	2h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00792

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C91H144N30O17S1

Absent amino acids CDEHINPSTVY

Theoretical pI 12.31

Acidic residues 0

Basic residues 6

Polar residues 1

Molecular weight (Average) 1962.4

Molecular weight (Monoisotopic) 1961.1

Common amino acids KR

Net charge 6

Instability index (II) 64.37

Aliphatic index 39.33

Grand average of hydropathicity (GRAVY) -1.253

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 5.605

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28961215

Title Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines

Doi 10.3390/molecules22101641

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available