LfcinB (17-31)

General Information


DCTPep ID  DCTPep00792

Peptide Name   LfcinB (17-31)

Sequence  FKARRWQWRMKKLGA

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Bovine Lactoferricin

Type  Native peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma IC50>102 μM MTT assay 2h 1
MDA-MB-468 Breast adenocarcinoma IC50>102 μM MTT assay 2h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00792

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C91H144N30O17S1

Absent amino acids  CDEHINPSTVY

Theoretical pI  12.31

Acidic residues  0

Basic residues  6

Polar residues  1

Molecular weight (Average)  1962.4

Molecular weight (Monoisotopic)  1961.1

Common amino acids  KR

Net charge  6

Instability index (II)  64.37

Aliphatic index  39.33

Grand average of hydropathicity (GRAVY)  -1.253

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 5.605

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28961215

Title  Antibacterial Synthetic Peptides Derived from Bovine Lactoferricin Exhibit Cytotoxic Effect against MDA-MB-468 and MDA-MB-231 Breast Cancer Cell Lines

Doi 10.3390/molecules22101641

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.