Peptide Libraray

PSN-PC

General Information

DCTPep ID DCTPep00804

Peptide Name PSN-PC

Sequence FLSLIPKIATGIAALAKHL

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Phyllomedusa camba

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	IC50=2.85µM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: 100% Hemolysis=64µM; Horse erythrocytes=50% Hemolysis=23µM

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=51.83µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00804

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C95H161N23O22

Absent amino acids CDEMNQRVWY

Theoretical pI 10.00

Acidic residues 0

Basic residues 3

Polar residues 3

Molecular weight (Average) 1977.46

Molecular weight (Monoisotopic) 1976.22

Common amino acids AL

Net charge 3

Instability index (II) -5.45

Aliphatic index 164.74

Grand average of hydropathicity (GRAVY) 1.274

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29112170

Title PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell

Doi 10.3390/molecules22111896

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available