This work is licensed under a Creative Commons Attribution 4.0 International License.
Lynronne-2
General Information
DCTPep ID DCTPep00809
Peptide Name Lynronne-2
Sequence HLRRINKLLTRIGLYRHAFG
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Not active up to 128 µg/ml | Not available | Not available | 1 |
Hemolytic Activity Human erythrocytes: 20% Hemolysis=500µg/ml; Sheep erythrocytes: 25% Hemolysis=500µg/ml
Normal (non-cancerous) Cytotoxicity HUVEC: Not active up to 128 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00809
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C111H184N38O24
Absent amino acids CDEMPQSVW
Theoretical pI 12.01
Acidic residues 0
Basic residues 7
Polar residues 5
Molecular weight (Average) 2434.92
Molecular weight (Monoisotopic) 2433.43
Common amino acids LR
Net charge 7
Instability index (II) 56.54
Aliphatic index 122.00
Grand average of hydropathicity (GRAVY) -0.290
Half Life
3.5 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.612
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29214045
Title The rumen microbiome: an underexplored resource for novel antimicrobial discovery
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.