Peptide Libraray

Lynronne-1

General Information

DCTPep ID DCTPep00810

Peptide Name Lynronne-1

Sequence LPRRNRWSKIWKKVVTVFS

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	IC50=45.9µg/ml	Not available	Not available	1

Hemolytic Activity Human erythrocytes: 20% Hemolysis=500µg/ml; Sheep erythrocytes: 10% Hemolysis=500µg/ml; Horse erythrocytes:0% Hemolysis=536µg/ml

Normal (non-cancerous) Cytotoxicity HUVEC: LC50=98.1µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00810

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C113H182N34O24

Absent amino acids ACDEGHMQY

Theoretical pI 12.31

Acidic residues 0

Basic residues 6

Polar residues 4

Molecular weight (Average) 2400.9

Molecular weight (Monoisotopic) 2399.41

Common amino acids KRV

Net charge 6

Instability index (II) 69.03

Aliphatic index 86.84

Grand average of hydropathicity (GRAVY) -0.563

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.582

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29214045

Title The rumen microbiome: an underexplored resource for novel antimicrobial discovery

Doi 10.1038/s41522-017-0042-1

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available