This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 fragment KR-12
General Information
DCTPep ID DCTPep00813
Peptide Name LL-37 fragment KR-12
Sequence KRIVQRIKDFLR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937/GTB | Adult acute monocytic leukemia; Acute monoblastic/monocytic leukemia | 15% Killing=100 µM | FDA cytotoxicity assay | 72h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>80 µM
Normal (non-cancerous) Cytotoxicity CEM-SS cells: 50% cell death >63.5 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H126N24O16
Absent amino acids ACEGHMNPSTWY
Theoretical pI 11.72
Acidic residues 1
Basic residues 5
Polar residues 0
Molecular weight (Average) 1571.93
Molecular weight (Monoisotopic) 1570.98
Common amino acids R
Net charge 4
Instability index (II) 31.95
Aliphatic index 121.67
Grand average of hydropathicity (GRAVY) -0.708
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29430821
Title Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity
Year 2018
Literature 2
Pubmed ID 18591279
Title Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins
Year 2008
Literature 3
Pubmed ID 32153522
Title Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.