This work is licensed under a Creative Commons Attribution 4.0 International License.
[Phe]2 -Dec-NH2
General Information
DCTPep ID DCTPep00819
Peptide Name [Phe]2 -Dec-NH2
Sequence SFLSLIRKLIT
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide (Derived from Decoralin)
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=50.0 µmol/L | MTT assay | 24h | 1 |
Hemolytic Activity Human red blood cells: MHC=3.12 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C61H107N15O15
Absent amino acids ACDEGHMNPQVWY
Theoretical pI 11.00
Acidic residues 0
Basic residues 2
Polar residues 3
Molecular weight (Average) 1290.61
Molecular weight (Monoisotopic) 1289.81
Common amino acids L
Net charge 2
Instability index (II) 1.37
Aliphatic index 177.27
Grand average of hydropathicity (GRAVY) 1.136
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30013694
Title Natural and redesigned wasp venom peptides with selective antitumoral activity
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.