Peptide Libraray

[Phe]6 -Dec[Thr]11-Dec-NH2

General Information

DCTPep ID DCTPep00821

Peptide Name [Phe]6 -Dec[Thr]11-Dec-NH2

Sequence SLLSLFRKLI

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide (Derived from Decoralin)

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50=50.0 µmol/L	MTT assay	24h	1

Hemolytic Activity Human red blood cells: MHC=12.50 μmol/L

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C57H100N14O13

Absent amino acids ACDEGHMNPQTVWY

Theoretical pI 11.00

Acidic residues 0

Basic residues 2

Polar residues 2

Molecular weight (Average) 1189.51

Molecular weight (Monoisotopic) 1188.76

Common amino acids L

Net charge 2

Instability index (II) 0.51

Aliphatic index 195.00

Grand average of hydropathicity (GRAVY) 1.250

Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30013694

Title Natural and redesigned wasp venom peptides with selective antitumoral activity

Doi 10.3762/bjoc.14.144

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available