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Decoralin, Dec-NH2
General Information
DCTPep ID DCTPep00823
Peptide Name Decoralin, Dec-NH2
Sequence SLLSLIRKLIT
Sequence Length 11
UniProt ID P85870
PubChem CID Not available
Origin Oreumenes decoratus
Type Native peptide
Classification
ACP Tumor active peptide Membrane lysis Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 1205Lu | Melanoma | EC50=18±1 μM | MTT assay | 24/72 h | 2 |
| MCF-7 | Invasive breast carcinoma of no special type | EC50=19±1 μM | MTT assay | 24/72 h | 2 |
| A549 | Lung adenocarcinoma | EC50=28±1 μM | MTT assay | 24/72 h | 2 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | EC50=40±1 μM | MTT assay | 24/72 h | 2 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=12.5 µmol/L | MTT assay | 24h | 1 |
Hemolytic Activity Human red blood cells: MHC=1.56 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2N9A
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C58H109N15O15
Absent amino acids ACDEFGHMNPQVWY
Theoretical pI 11.00
Acidic residues 0
Basic residues 2
Polar residues 3
Molecular weight (Average) 1256.59
Molecular weight (Monoisotopic) 1255.82
Common amino acids L
Net charge 2
Instability index (II) 1.37
Aliphatic index 212.73
Grand average of hydropathicity (GRAVY) 1.227
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30013694
Title Natural and redesigned wasp venom peptides with selective antitumoral activity
Year 2018
Literature 2
Pubmed ID 26119906
Title Multidimensional Design of Anticancer Peptides
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3177
This work is licensed under a Creative Commons Attribution 4.0 International License.