Peptide Libraray

[Leu]11 -Dec-NH2

General Information

DCTPep ID DCTPep00825

Peptide Name [Leu]11 -Dec-NH2

Sequence SLLSLIRKLLT

Sequence Length 11

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide (Derived from Decoralin)

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50=12.5 µmol/L	MTT assay	24h	1

Hemolytic Activity Human red blood cells: MHC=25.00 μmol/L

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C58H109N15O15

Absent amino acids ACDEFGHMNPQVWY

Theoretical pI 11.00

Acidic residues 0

Basic residues 2

Polar residues 3

Molecular weight (Average) 1256.59

Molecular weight (Monoisotopic) 1255.82

Common amino acids L

Net charge 2

Instability index (II) 1.37

Aliphatic index 212.73

Grand average of hydropathicity (GRAVY) 1.164

Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30013694

Title Natural and redesigned wasp venom peptides with selective antitumoral activity

Doi 10.3762/bjoc.14.144

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available