[Leu]11 -Dec-NH2

General Information


DCTPep ID  DCTPep00825

Peptide Name   [Leu]11 -Dec-NH2

Sequence  SLLSLIRKLLT

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide (Derived from Decoralin)

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type IC50=12.5 µmol/L MTT assay 24h 1

Hemolytic Activity  Human red blood cells: MHC=25.00 μmol/L

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C58H109N15O15

Absent amino acids  ACDEFGHMNPQVWY

Theoretical pI  11.00

Acidic residues  0

Basic residues  2

Polar residues  3

Molecular weight (Average)  1256.59

Molecular weight (Monoisotopic)  1255.82

Common amino acids  L

Net charge  2

Instability index (II)  1.37

Aliphatic index  212.73

Grand average of hydropathicity (GRAVY)  1.164

Half Life 
  1.9 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30013694

Title  Natural and redesigned wasp venom peptides with selective antitumoral activity

Doi 10.3762/bjoc.14.144

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.