L10, 11-DPS3

General Information


DCTPep ID  DCTPep00829

Peptide Name   L10, 11-DPS3

Sequence  ALWKDILKNLLKAALNEINQIVQ

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  skin secretion of Phyllomedusa sauvagii

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
NCI-H157 Lung squamous cell carcinoma IC50=0.12 μM MTT assay 24h 1
PC-3 Prostate carcinoma IC50=1.85 μM MTT assay 24h 1

Hemolytic Activity  Horse blood cells: HC50=3.44 μM

Normal (non-cancerous) Cytotoxicity  HMEC-1: IC50=8.76 μM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00829

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C122H206N32O33

Absent amino acids  CFGHMPRSTY

Theoretical pI  8.54

Acidic residues  2

Basic residues  3

Polar residues  3

Molecular weight (Average)  2649.17

Molecular weight (Monoisotopic)  2647.54

Common amino acids  L

Net charge  1

Instability index (II)  22.26

Aliphatic index  161.30

Grand average of hydropathicity (GRAVY)  0.217

Half Life 
  4.4 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.076

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30087268

Title  Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii

Doi 10.3390/toxins10080320

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.