Peptide Libraray

K5, 17-DPS3

General Information

DCTPep ID DCTPep00830

Peptide Name K5, 17-DPS3

Sequence ALWKKILKNAGKAALNKINQIVQ

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin skin secretion of Phyllomedusa sauvagii

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	IC50=18.20 μM	MTT assay	24h	1
PC-3	Prostate carcinoma	IC50=18.20 μM	MTT assay	24h	1

Hemolytic Activity Horse blood cells: HC50=14.98 μM

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=123.00 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00830

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C118H204N34O29

Absent amino acids CDEFHMPRSTY

Theoretical pI 10.60

Acidic residues 0

Basic residues 5

Polar residues 4

Molecular weight (Average) 2563.13

Molecular weight (Monoisotopic) 2561.55

Common amino acids K

Net charge 5

Instability index (II) 16.8

Aliphatic index 131.74

Grand average of hydropathicity (GRAVY) -0.087

Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.146

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30087268

Title Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii

Doi 10.3390/toxins10080320

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available