LP-40

General Information


DCTPep ID  DCTPep00837

Peptide Name   LP-40

Sequence  YTSLIHSLIEESQNQQEKNEQELLELDX

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MT-4 Human acute lymphoblastic leukemia cell line 50% Cytotoxicity=366.3±119.08µM CellTiter 96 AQueous One Solution assay 48h 1
TZM-bl Human papillomavirus-related endocervical adenocarcinoma 50% Cytotoxicity=800.8±62.29µM CellTiter 96 AQueous One Solution assay 48h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK293T cells: 50% Cytotoxicity=408±40.1 µM; PBMC: 50% Cytotoxicity=212.6±25.71 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  X(28)= Lysine with palmitoylated side group

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30089693

Title  Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

Doi 10.1128/JVI.01088-18

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.