This work is licensed under a Creative Commons Attribution 4.0 International License.
VGB
General Information
DCTPep ID DCTPep00838
Peptide Name VGB
Sequence CIKPHQGQHICNDE
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 4T1 | Malignant neoplasms of the mouse mammary gland | IC50=0.61 μM | MTT assay | 48h | 1 |
| U-87MG ATCC | Glioblastoma | IC50=0.92 μM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00838
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys11
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C66H104N22O22S2
Absent amino acids AFLMRSTVWY
Theoretical pI 5.99
Acidic residues 2
Basic residues 3
Polar residues 4
Molecular weight (Average) 1621.81
Molecular weight (Monoisotopic) 1620.71
Common amino acids CHIQ
Net charge 1
Instability index (II) 29.22
Aliphatic index 55.71
Grand average of hydropathicity (GRAVY) -1.129
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.077, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30251659
Title Dual blockade of VEGFR1 and VEGFR2 by a novel peptide abrogates VEGF-driven angiogenesis, tumor growth, and metastasis through PI3K/AKT and MAPK/ERK1/2 pathway
Doi 10.1016/j.bbagen.2018.08.013
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.