Peptide Libraray

P-MerP fragment [F5K,A6L,A9R,V13K,V14I]

General Information

DCTPep ID DCTPep00849

Peptide Name P-MerP fragment [F5K,A6L,A9R,V13K,V14I]

Sequence PMKKLKLALRLAAKIAPVW

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HT-29	Colon adenocarcinoma	Not active up to 100 µM	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	Not active up to 100 µM	MTT assay	24h	1
PC-3	Prostate carcinoma	Not active up to 100 µM	MTT assay	24h	1

Hemolytic Activity Human erythrocytes: Not active up to 100 µM

Normal (non-cancerous) Cytotoxicity 3T3-L1: Not active up to 100 µM; HUVEC: Not active up to 100 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00849

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C103H179N27O20S1

Absent amino acids CDEFGHNQSTY

Theoretical pI 11.33

Acidic residues 0

Basic residues 5

Polar residues 0

Molecular weight (Average) 2147.78

Molecular weight (Monoisotopic) 2146.35

Common amino acids AKL

Net charge 5

Instability index (II) 18.04

Aliphatic index 138.95

Grand average of hydropathicity (GRAVY) 0.463

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.561

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30346140

Title A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies

Doi 10.1021/acsinfecdis.8b00219

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available