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P-52
General Information
DCTPep ID DCTPep00864
Peptide Name P-52
Sequence WEQKIEELLKKAEEQQKKNEEELKKLEK
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MT-4 | Human acute lymphoblastic leukemia cell line | 50% Cytotoxicity=108.32µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| TZM-bl | Human papillomavirus-related endocervical adenocarcinoma | 50% Cytotoxicity=85.83µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity PBMC: 50% Cytotoxicity=80.45 µM; HEK293T cells: 50% Cytotoxicity=78.52 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00864
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C156H261N41O51
Absent amino acids CDFGHMPRSTVY
Theoretical pI 5.36
Acidic residues 9
Basic residues 8
Polar residues 1
Molecular weight (Average) 3527.03
Molecular weight (Monoisotopic) 3524.91
Common amino acids E
Net charge -1
Instability index (II) 80.41
Aliphatic index 73.21
Grand average of hydropathicity (GRAVY) -2.004
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.559
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30716118
Title Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques
Doi 10.1371/journal.ppat.1007552
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.