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LP-83
General Information
DCTPep ID DCTPep00868
Peptide Name LP-83
Sequence WEQKIEELLKKAEEQQKKNEEELKKLEKC
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| TZM-bl | Human papillomavirus-related endocervical adenocarcinoma | 50% Cytotoxicity=12.34µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| C8166 | Human T cell leukemia cells | 50% Cytotoxicity=19.19µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| MT-4 | Human acute lymphoblastic leukemia cell line | 50% Cytotoxicity=19.65µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 50% Cytotoxicity=9.97µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity PBMC: 50% Cytotoxicity=40.27 µM; HEK293T cells: 50% Cytotoxicity=25.31 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00868
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Chol-NH2
Other Modification None
Chiral L
Physicochemical Information
Formula C159H266N42O52S1
Absent amino acids DFGHMPRSTVY
Theoretical pI 5.36
Acidic residues 9
Basic residues 8
Polar residues 2
Molecular weight (Average) 3630.17
Molecular weight (Monoisotopic) 3627.92
Common amino acids E
Net charge -1
Instability index (II) 77.99
Aliphatic index 70.69
Grand average of hydropathicity (GRAVY) -1.848
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.515, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.515, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30867304
Title Design and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.