Peptide Libraray

BMAP-27(1-18)

General Information

DCTPep ID DCTPep00870

Peptide Name BMAP-27(1-18)

Sequence GRFKRFRKKFKKLFKKLS

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	50% Cytotoxicity>100 µM	MTT assay	2 days	1
MDA-MB-361	Breast adenocarcinoma	50% Cytotoxicity>100 µM	MTT assay	2 days	1

Hemolytic Activity Human erythrocytes: 10% Hemolysis<400 µM; 50% Hemolysis>200 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00870

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C113H188N34O20

Absent amino acids ACDEHIMNPQTVWY

Theoretical pI 12.32

Acidic residues 0

Basic residues 10

Polar residues 2

Molecular weight (Average) 2342.95

Molecular weight (Monoisotopic) 2341.47

Common amino acids K

Net charge 10

Instability index (II) -6.93

Aliphatic index 43.33

Grand average of hydropathicity (GRAVY) -1.289

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31226350

Title Structural analysis and mode of action of BMAP-27, a cathelicidin-derived antimicrobial peptide

Doi 10.1016/j.peptides.2019.170106

Year 2019

Literature 2

Pubmed ID 21497177

Title Cell selectivity, mechanism of action and LPS-neutralizing activity of bovine myeloid antimicrobial peptide-18 (BMAP-18) and its analogs

Doi 10.1016/j.peptides.2011.03.024

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available