Peptide Libraray

CLP

General Information

DCTPep ID DCTPep00875

Peptide Name CLP

Sequence LP

Sequence Length 2

UniProt ID Not available

PubChem CID Not available

Origin marine natural metabolite

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-468	Breast adenocarcinoma	IC50=67.4 μM	MTT assay	48h	1
MDA-MB-231	Breast adenocarcinoma	IC50=73.4 μM	MTT assay	48h	1

Hemolytic Activity Human red blood cells (RBC): LC50>401 μM

Normal (non-cancerous) Cytotoxicity MCF-12A: IC50>100 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Leu1<--->Pro2

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31669320

Title Marine natural compound cyclo(L-leucyl-L-prolyl) peptide inhibits migration of triple negative breast cancer cells by disrupting interaction of CD151 and EGFR signaling

Doi 10.1016/j.cbi.2019.108872

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available