Peptide Libraray

Bac5 (1-17)[F2W; P4,9R; P17W]

General Information

DCTPep ID DCTPep00903

Peptide Name Bac5 (1-17)[F2W; P4,9R; P17W]

Sequence RWRRPIRRRPIRPPFYW

Sequence Length 17

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MEC-1	Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia	19% Killing=32µM	MTT assay	20h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00903

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C114H174N40O19

Absent amino acids ACDEGHKLMNQSTV

Theoretical pI 12.40

Acidic residues 0

Basic residues 7

Polar residues 1

Molecular weight (Average) 2408.89

Molecular weight (Monoisotopic) 2407.39

Common amino acids R

Net charge 7

Instability index (II) 213.91

Aliphatic index 45.88

Grand average of hydropathicity (GRAVY) -1.718

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 12490
Abs 0.1% (=1 g/l) 5.185

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31692278

Title Proline-Rich Peptides With Improved Antimicrobial Activity Against E. Coli, K. Pneumoniae, and A. Baumannii.

Doi 10.1002/cmdc.201900465

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available