Bac5 (1-17)[F2W, P4W]

General Information


DCTPep ID  DCTPep00907

Peptide Name   Bac5 (1-17)[F2W, P4W]

Sequence  RWRWPIRRPPIRPPFYP

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MEC-1 Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia 8% Killing=32µM MTT assay 20h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00907

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C112H164N34O19

Absent amino acids  ACDEGHKLMNQSTV

Theoretical pI  12.18

Acidic residues  0

Basic residues  5

Polar residues  1

Molecular weight (Average)  2290.75

Molecular weight (Monoisotopic)  2289.29

Common amino acids  P

Net charge  5

Instability index (II)  193.58

Aliphatic index  45.88

Grand average of hydropathicity (GRAVY)  -1.376

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 12490
  Abs 0.1% (=1 g/l) 5.452

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31692278

Title  Proline-Rich Peptides With Improved Antimicrobial Activity Against E. Coli, K. Pneumoniae, and A. Baumannii.

Doi 10.1002/cmdc.201900465

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.