This work is licensed under a Creative Commons Attribution 4.0 International License.
Astacidin PcAst-1a
General Information
DCTPep ID DCTPep00936
Peptide Name Astacidin PcAst-1a
Sequence SNGYRPAYRPAYRPSYRP
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| T24 | Bladder carcinoma | IC50>100 µM | MTT assay | 24h | 1 |
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Not active up to 100 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00936
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H143N31O26
Absent amino acids CDEFHIKLMQTVW
Theoretical pI 10.42
Acidic residues 0
Basic residues 4
Polar residues 8
Molecular weight (Average) 2171.41
Molecular weight (Monoisotopic) 2170.08
Common amino acids PRY
Net charge 4
Instability index (II) 33.7
Aliphatic index 11.11
Grand average of hydropathicity (GRAVY) -1.750
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5960
Abs 0.1% (=1 g/l) 2.745
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31884202
Title Identification and functional characterization of the astacidin family of proline-rich host defence peptides (PcAst) from the red swamp crayfish (Procambarus clarkii, Girard 1852)
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.