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Astacidin PcAst-1b/c
General Information
DCTPep ID DCTPep00937
Peptide Name Astacidin PcAst-1b/c
Sequence SNVYRPPPYRPVYRPLRRPGYRP
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Procambarus clarkii; Procambarus clarkii
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| T24 | Bladder carcinoma | IC50>100 µM | MTT assay | 24h | 1 |
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Not active up to 100 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00937
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H202N42O30
Absent amino acids ACDEFHIKMQTW
Theoretical pI 11.38
Acidic residues 0
Basic residues 6
Polar residues 7
Molecular weight (Average) 2857.32
Molecular weight (Monoisotopic) 2855.56
Common amino acids P
Net charge 6
Instability index (II) 70.18
Aliphatic index 42.17
Grand average of hydropathicity (GRAVY) -1.561
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5960
Abs 0.1% (=1 g/l) 2.086
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31884202
Title Identification and functional characterization of the astacidin family of proline-rich host defence peptides (PcAst) from the red swamp crayfish (Procambarus clarkii, Girard 1852)
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.