Peptide Libraray

Combi-1

General Information

DCTPep ID DCTPep00947

Peptide Name Combi-1

Sequence RRWWRF

Sequence Length 6

UniProt ID Not available

PubChem CID Not available

Origin porcine cathelicidin peptide

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	IC50 ≥ 65 µM	MTT assay	24h	1

Hemolytic Activity RBC: IC50 ≥ 65 µM

Normal (non-cancerous) Cytotoxicity PBMC: IC50 ≥ 65 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C49H67N17O7

Absent amino acids ACDEGHIKLMNPQSTVY

Theoretical pI 12.30

Acidic residues 0

Basic residues 3

Polar residues 0

Molecular weight (Average) 1006.18

Molecular weight (Monoisotopic) 1005.54

Common amino acids R

Net charge 3

Instability index (II) 199.27

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -2.083

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 10.932

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32126228

Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Doi 10.1016/j.bbamem.2020.183228

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available