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Tritrpticin
General Information
DCTPep ID DCTPep00975
Peptide Name Tritrpticin
Sequence VRRFPWWWPFLRR
Sequence Length 13
UniProt ID Not available
PubChem CID 16134657
Origin porcine cathelicidin peptide
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-361 | Breast adenocarcinoma | IC50=142 µg/ml | MTT assay | Not available | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=18.3 µM | MTT assay | 24h | 1 |
| A549 | Lung adenocarcinoma | IC50>200 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity RBC: IC50 ≥ 65 µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50=40.6 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00975
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C96H132N28O14
Absent amino acids ACDEGHIKMNQSTY
Theoretical pI 12.48
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1902.28
Molecular weight (Monoisotopic) 1901.05
Common amino acids R
Net charge 4
Instability index (II) 139.58
Aliphatic index 52.31
Grand average of hydropathicity (GRAVY) -0.792
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 8.674
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32126228
Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Doi 10.1016/j.bbamem.2020.183228
Year 2020
Literature 2
Pubmed ID 18815734
Title Effect of dimerization of a beta-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.