Peptide Libraray

Tritrp-W78Y

General Information

DCTPep ID DCTPep00978

Peptide Name Tritrp-W78Y

Sequence VRRFPWYYPFLRR

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin porcine cathelicidin peptide

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	IC50=25.6 µM	MTT assay	24h	1

Hemolytic Activity RBC: IC50 ≥ 65 µM

Normal (non-cancerous) Cytotoxicity PBMC: IC50 ≥ 65 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00978

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C92H130N26O16

Absent amino acids ACDEGHIKMNQST

Theoretical pI 11.55

Acidic residues 0

Basic residues 4

Polar residues 2

Molecular weight (Average) 1856.21

Molecular weight (Monoisotopic) 1855.02

Common amino acids R

Net charge 4

Instability index (II) 158.57

Aliphatic index 52.31

Grand average of hydropathicity (GRAVY) -0.854

Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 8480
Abs 0.1% (=1 g/l) 4.568

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32126228

Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Doi 10.1016/j.bbamem.2020.183228

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available