Tritrp-W78Y

General Information


DCTPep ID  DCTPep00978

Peptide Name   Tritrp-W78Y

Sequence  VRRFPWYYPFLRR

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  porcine cathelicidin peptide

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia IC50=25.6 µM MTT assay 24h 1

Hemolytic Activity  RBC: IC50 ≥ 65 µM

Normal (non-cancerous) Cytotoxicity  PBMC: IC50 ≥ 65 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00978

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C92H130N26O16

Absent amino acids  ACDEGHIKMNQST

Theoretical pI  11.55

Acidic residues  0

Basic residues  4

Polar residues  2

Molecular weight (Average)  1856.21

Molecular weight (Monoisotopic)  1855.02

Common amino acids  R

Net charge  4

Instability index (II)  158.57

Aliphatic index  52.31

Grand average of hydropathicity (GRAVY)  -0.854

Half Life 
  100 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 8480
  Abs 0.1% (=1 g/l) 4.568

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 32126228

Title  Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Doi 10.1016/j.bbamem.2020.183228

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.