This work is licensed under a Creative Commons Attribution 4.0 International License.
ROS modulator 1 (58-78)
General Information
DCTPep ID DCTPep00984
Peptide Name ROS modulator 1 (58-78)
Sequence KTMMQSGGTFGTFMAIGMGIR
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 20% Killing=256 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Mouse erythrocytes: 20% Hemolysis=256µg/ml
Normal (non-cancerous) Cytotoxicity HEK293: 20% Hemolysis=256µg/ml; HUVEC: 20% Hemolysis=256µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00984
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H156N26O27S4
Absent amino acids CDEHLNPVWY
Theoretical pI 11.00
Acidic residues 0
Basic residues 2
Polar residues 9
Molecular weight (Average) 2222.68
Molecular weight (Monoisotopic) 2221.05
Common amino acids G
Net charge 2
Instability index (II) 36.86
Aliphatic index 41.90
Grand average of hydropathicity (GRAVY) 0.343
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32291307
Title Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.