This work is licensed under a Creative Commons Attribution 4.0 International License.
Figainin 2
General Information
DCTPep ID DCTPep00996
Peptide Name Figainin 2
Sequence FLGAILKIGHALAKTVLPMVTNAFKPKQ
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Boana raniceps
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | IC50=12.8 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=15.3 µM | MTT assay | 24h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Not toxic up to 25 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 9% Hemolysis=16µM; 23% Hemolysis=32µM; 50% Hemolysis=48.9µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00996
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C142H236N36O33S1
Absent amino acids CDERSWY
Theoretical pI 10.48
Acidic residues 0
Basic residues 5
Polar residues 5
Molecular weight (Average) 3007.72
Molecular weight (Monoisotopic) 3005.76
Common amino acids AKL
Net charge 5
Instability index (II) 3.61
Aliphatic index 118.57
Grand average of hydropathicity (GRAVY) 0.575
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32443921
Title Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.