This work is licensed under a Creative Commons Attribution 4.0 International License.
Kassinatuerin-3
General Information
DCTPep ID DCTPep00998
Peptide Name Kassinatuerin-3
Sequence FIQHLIPLIPHAIQGIKDIF
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Skin Secretion of the African Frog, Kassina senegalensis
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H460 | Lung large cell carcinoma | IC50=1.67 μM | MTT assay | 24h | 1 |
| NCI-H838 | Lung adenocarcinoma | IC50=10.3 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | IC50=13.20 μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | IC50=21.54 μM | MTT assay | 24h | 1 |
| LNCaP | Prostate carcinoma | IC50=3.79 μM | MTT assay | 24h | 1 |
| NCI-H23 | Lung adenocarcinoma | IC50=4.52 μM | MTT assay | 24h | 1 |
Hemolytic Activity Human RBCs: Kassinatuerin-3 produced no detectable hemolysis activity up to a concentration of 160 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00998
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C113H177N27O25
Absent amino acids CEMNRSTVWY
Theoretical pI 6.92
Acidic residues 1
Basic residues 3
Polar residues 1
Molecular weight (Average) 2313.81
Molecular weight (Monoisotopic) 2312.34
Common amino acids I
Net charge 2
Instability index (II) -1.87
Aliphatic index 161.00
Grand average of hydropathicity (GRAVY) 0.880
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32630734
Title A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.