This work is licensed under a Creative Commons Attribution 4.0 International License.
Desmethoxymajusculamide C
General Information
DCTPep ID DCTPep01001
Peptide Name Desmethoxymajusculamide C
Sequence XXGXGXXXA
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Lyngbya majuscula
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | IC50=0.02µM | Concentration-cell number assay | 120h | 1 |
| MDA-MB-435 | Amelanotic melanoma | IC50=0.022µM | Concentration-cell number assay | 120h | 1 |
| NCI-H460 | Lung large cell carcinoma | IC50=0.063µM | Concentration-cell number assay | 120h | 1 |
| N2a | Mouse neuroblastoma cells | IC50>1.0µM | Concentration-cell number assay | 120h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: X(1)<--->Ala9
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19489598
Title Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.