Peptide Libraray

Esculentin (1-21)

General Information

DCTPep ID DCTPep01005

Peptide Name Esculentin (1-21)

Sequence GIFSKLAGKKIKNLLISGLKG

Sequence Length 21

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	50% Cell death=150 µM	MTT assay	24h	1

Hemolytic Activity Sheep erythrocytes: 10% Hemolysis=64 µM

Normal (non-cancerous) Cytotoxicity HaCat: 20% Killing=64 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01005

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C102H181N27O25

Absent amino acids CDEHMPQRTVWY

Theoretical pI 10.60

Acidic residues 0

Basic residues 5

Polar residues 7

Molecular weight (Average) 2185.72

Molecular weight (Monoisotopic) 2184.37

Common amino acids K

Net charge 5

Instability index (II) -18.78

Aliphatic index 134.76

Grand average of hydropathicity (GRAVY) 0.338

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32722535

Title Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities

Doi 10.3390/antibiotics9080448

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available