Peptide Libraray

Granuliberin-SSa

General Information

DCTPep ID DCTPep01008

Peptide Name Granuliberin-SSa

Sequence FIFLPIFRRPVS

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Glandirana susurra

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	50.5% Killing=32µg/ml	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity COS-7: 88.5% Killing=32µg/ml; CPAE: 99.2% Killing=32µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C75H114N18O14

Absent amino acids ACDEGHKMNQTWY

Theoretical pI 12.00

Acidic residues 0

Basic residues 2

Polar residues 1

Molecular weight (Average) 1491.84

Molecular weight (Monoisotopic) 1490.88

Common amino acids F

Net charge 2

Instability index (II) 105.05

Aliphatic index 121.67

Grand average of hydropathicity (GRAVY) 1.033

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32751229

Title Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens

Doi 10.3390/antibiotics9080457

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available